HUNTINGTON DISEASE
-Progressive disorder of motor, cognitive, and psychiatric changes
-mean age of onset is 35-44 years and after, the median survival time is 15-18 years
Early Stage
-subtle changes in coordination
-minor chorea (involuntary movements)
-difficulty in mental planning
-depressed or irritable mood
Next Stage
-chorea becomes more prominent
-increasing difficulty with voluntary activity
-worsening dysarthria and dysphagia
Late Stages
-behavior problems are gradually lessened
-motor disability becomes severe
-individual is totally dependent, mute, and incontinent
-huntington disease is associated with increased CAG repeats in the HD gene on chromosome 4
-autosomal dominant
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